The band met while its members attended the Claremont Colleges. Keith Murray and Chris Cain attended Pomona College; Michael Tapper attended Harvey Mudd College just a few blocks away. The trio formed the band after they had graduated, and have frequently performed free shows at the colleges ever since.
The band has released two self-made LPs and two self-made EPs - Safety, Fun and Learning (In That Order) LP, Bitchin! LP, In Action EP, and The Wolf΄s Hour EP - and released their major label debut LP, With Love and Squalor on EMI/Virgin Records. The first three singles are "Nobody Move, Nobody Get Hurt", "The Great Escape" and "It΄s a Hit". Every song has a video, and they are all available on the band΄s most recent release, Crap Attack, which also includes b-sides and a live show.
In 2006, We Are Scientists began touring with Arctic Monkeys, Maxïmo Park and Mystery Jets as part of the NME Shockwaves Tour, playing Cardiff and Nottingham en route.
Their music videos typically feature surreal situations such as the band being chased by a man in a grizzly bear costume ("Nobody Move, Nobody Get Hurt"), having boxing matches ("It΄s a Hit"), and the three being seemingly connected at the hip throughout an entire day΄s activities ("The Great Escape"). Three of the videos are directed by Akiva Schaffer. The video for "In Action" was directed by Eric Gross, a college friend who became a filmmaker.
Their single ΄The Great Escape΄ got a lot of UK recognition from being available as the free download of the week on iTunes.
The band performed "Nobody Move, Nobody Get Hurt" on the December 19, 2005 episode of the Late Show with David Letterman, and "It΄s a Hit" on the March 14, 2006 episode of Late Night with Conan O΄Brien. Throughout February 2006, "The Great Escape" was heard in a commercial for the 2006 Winter Olympics and on another commercial advertising BBC Radio stations. An instrumental version of "The Great Escape" has been used in a commercial from various television comedy shows airing on British station E4. It has also been used in the introductions for various Sky Sports channels
The band obtained the Xpression FM number one single on 8th May 2006 with "Nobody Move, Nobody Get Hurt".
In 2007 Was Nominated for NME Best International Band Award later to be won by My Chemical Romance
It is reported on their website΄s news page that they are currently working on a new album, with the name of the album yet to be announced (they΄ve been joking around with some "tentative titles.") On a MySpace bulletin posted by the band on June 26, 2007, the band said that they΄re in Sausalito, California, recording the album. The band has said that some of the "tentative titles" are "What # of $ Do That Cost?", "Fluffin΄ Tha Cushions", "Onlookerswatchedinhorror", "Mermaid Stewwwww", "Do Smoke Detectors Detect The Smell Of Smoke?", "YOU ASKED YOU FIND OUT fu*k UP SECRET", "Collective Soul", "DJ Server Wars" and "You Bang, She Bangs, You Want Some...Unh!". According to What΄s The Word, the official title of this album will be Brain Thrust Mastery, after their seminars around the UK and will be released in the UK on March 17 2008.
They toured with Kaiser Chiefs at the end of 2007.
It was announced on the 1st November 2007 that drummer Michael Tapper would be leaving the band prior to their UK tour.